Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain.

Md Shafiqur RahmanBendik S WinsvoldSergio O Chavez ChavezSigrid BørteYakov A TsepilovSodbo Zh Sharapovnull nullYurii S AulchenkoKnut HagenEgil A ForsKristian HveemJohn Anker ZwartJoyce B van MeursMaxim B FreidinFrances Mk Williams

Published in: Annals of the rheumatic diseases (2021)

We report a novel association of RNF123 locus and a suggestive association of ATP2C1 locus with CWP. Both loci are consistent with a role of calcium regulation in CWP. The association with COMT, one of the most studied genes in chronic pain field, was not confirmed in the replication analysis.

Keyphrases

genome wide association study
chronic pain
genome wide
pain management
gene expression
transcription factor
dna damage response
solid state
genome wide identification