Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus.
Cathelijne HeymansI H de LangeK LenaertsL C G A KesselsM HadfouneG RademakersV MelotteW BoesmansB W KramerA H JobeM SaitoM W KempW G van GemertT G A M WolfsPublished in: Molecular medicine (Cambridge, Mass.) (2020)
The pattern of mucosal and submucosal inflammation, and ENS alterations in the fetus changed over time following IA LPS exposure. Although ENS damage seemed to recover after prolonged IA LPS exposure, additional postnatal inflammatory exposure, which a premature is likely to encounter, may further harm the ENS and influence functional outcome. In this context, 4 to 8 days of IA LPS exposure may form a period of increased ENS vulnerability and a potential window for optimal therapeutic strategies.