CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.

Wanli ZhaiXiongjun YeYinyin WangYarui FengYing WangYuting LinLidan DingLiu YangXuning WangYanshen KuangXinyuan FuY Eugene ChinBaoqing JiaBingtao ZhuFangli RenZhijie Chang

Published in: British journal of cancer (2021)

We propose that CREPT is a co-activator of STAT3 for recruiting p300. Our study provides an alternative strategy for the therapy of cancers related to STAT3.

Keyphrases

cell proliferation
genome wide
stem cells
nuclear factor
gene expression
inflammatory response
drug induced
childhood cancer