High-resolution analysis of individual spike peptide-specific CD4 + T-cell responses in vaccine recipients and COVID-19 patients.
Hendrik KarstenLeon CordsTim WestphalMaximilian KnappThomas Theo BrehmLennart HermanussenTill Frederik OmansenStefan SchmiedelRobin WoostVanessa DittSven PeineMarc LütgehetmannSamuel HuberChristin AckermannMelanie WittnerMarylyn Martina AddoAlessandro SetteJohn SidneyJulian Schulze Zur-WieschPublished in: Clinical & translational immunology (2022)
Both SARS-CoV-2 infection and vaccination prime broadly directed T-cell responses directed against the SARS-CoV-2 spike glycoprotein. This comprehensive high-resolution analysis of spike peptide specificities will be a useful resource for further investigation of spike-specific T-cell responses.