Melatonin receptor agonist ramelteon alleviates experimental acute ocular inflammation via HIF-1Α/VEGF/E-NOS signaling.
Gülşah UstaYalcın ErzurumluUmut KaracaIbrahim Aydın CandanMehtap SavranHalil AsciNursel HasseyidPublished in: European journal of ophthalmology (2022)
RML treatment reversed the changes in the HIF-1α /eNOS/ VEGF signaling pathway in LPS-induced uveitis in rats, preventing the progression of the damage and showed positive effects.
Keyphrases
- endothelial cells
- lps induced
- vascular endothelial growth factor
- signaling pathway
- inflammatory response
- oxidative stress
- pi k akt
- nitric oxide synthase
- liver failure
- respiratory failure
- juvenile idiopathic arthritis
- epithelial mesenchymal transition
- ankylosing spondylitis
- nitric oxide
- mouse model
- cell proliferation
- rheumatoid arthritis
- intensive care unit
- extracorporeal membrane oxygenation
- endoplasmic reticulum stress
- systemic lupus erythematosus
- smoking cessation
- mechanical ventilation