Mechanism of Xinfeng Capsule in the Treatment of Hypercoagulable State of Ankylosing Spondylitis Based on Data Mining and Network Pharmacology.
Xu LiJian LiuYanyan FangMingyu HeFanfan WangQi HanPublished in: BioMed research international (2022)
This study demonstrated that XFC can effectively improve the hypercoagulable state and the inflammatory indices of AS patients through data mining, and it has a strong correlation with the clinical improvement of inflammation. The active compounds of formononetin, triptolide, quercetin, and kaempferol may be the key active components of XFC in regulating AS, possibly through inhibiting the activation of NF-kappa B signaling pathway to improve hypercoagulable state.
Keyphrases
- signaling pathway
- ankylosing spondylitis
- oxidative stress
- end stage renal disease
- pi k akt
- nuclear factor
- electronic health record
- ejection fraction
- newly diagnosed
- chronic kidney disease
- big data
- disease activity
- rheumatoid arthritis
- epithelial mesenchymal transition
- induced apoptosis
- peritoneal dialysis
- machine learning
- artificial intelligence
- toll like receptor
- immune response
- combination therapy
- patient reported outcomes
- deep learning