Optimization of Thiazolidone Scaffolds Using Pocket Modeling for Development of Potential Secretory System Inhibitors of Mycobacterium tuberculosis.
Shivratna V KhareSujata P ChoudhariSiddharth P PhalleSantosh S KumbharPrafulla Balkrishna ChoudhariSambhaji R MasalAakash K PatilRakesh P DhavaleDurgacharan A BhagwatAtul M KadamPublished in: Turkish journal of pharmaceutical sciences (2019)
We found that Q30, M9, M26, U8, and R26 molecules had significant desirable biological activity and specific interactions with Sec of mycobacteria. Further optimization of these leads is necessary for the development of potential antimycobacterial drug candidates with fewer side effects.