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Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome.

John A KinkMichael A BellioMatthew H ForsbergAlexandra LoboAnna S ThickensBryson M LewisIrene M OngAisha KhanChristian M CapitiniPeiman Hematti
Published in: Stem cell research & therapy (2024)
LPS-EVs as an effective treatment for H-ARS can be produced using a scale-up development manufacturing process, representing an attractive off-the-shelf, cell-free therapy.
Keyphrases
  • cell free
  • bone marrow
  • liver failure
  • inflammatory response
  • intensive care unit
  • radiation therapy
  • drug induced
  • replacement therapy
  • hepatitis b virus
  • circulating tumor cells
  • smoking cessation
  • circulating tumor