Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome.
John A KinkMichael A BellioMatthew H ForsbergAlexandra LoboAnna S ThickensBryson M LewisIrene M OngAisha KhanChristian M CapitiniPeiman HemattiPublished in: Stem cell research & therapy (2024)
LPS-EVs as an effective treatment for H-ARS can be produced using a scale-up development manufacturing process, representing an attractive off-the-shelf, cell-free therapy.