Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET.
Alicia López-de-EguiletaCarmen LageSara López-GarcíaAna PozuetaMaría García-MartínezMartha KazimierczakMaría BravoMaría de Arcocha-TorresIgnacio BanzoJulio Jimenez-BonillaAndrea CerveróAlexander GoikoetxeaEloy Rodríguez-RodríguezPascual Sánchez-JuanAlfonso CasadoPublished in: PloS one (2020)
To our knowledge, the present study is the first measuring CT in eyes from MCI and dementia eyes positive to 11C-PiB PET/CT reporting a significant trend towards CT thinning in MCI patients which became more pronounced in dementia stage. We support further investigation involving larger and prospective OCT studies in AD population characterized with available biomarkers to describe whether choroidal vascular damage occurs specifically in prodromal stages of AD.
Keyphrases
- optical coherence tomography
- pet ct
- mild cognitive impairment
- positron emission tomography
- cognitive decline
- computed tomography
- diabetic retinopathy
- end stage renal disease
- image quality
- ejection fraction
- parkinson disease
- dual energy
- newly diagnosed
- chronic kidney disease
- healthcare
- optic nerve
- contrast enhanced
- cognitive impairment
- magnetic resonance
- prognostic factors
- patient reported outcomes
- adverse drug
- age related macular degeneration
- deep brain stimulation