A microglia clonal inflammatory disorder in Alzheimer's Disease.

Rocio VicarioStamatina FragkogianniLeslie WeberTomi LazarovYang HuSamantha Y HayashiBarbara P CraddockNicholas D SocciAraitz AlberdiAnn BaakoOyku AyMasato OgishiEstibaliz Lopez-RodrigoRajya KappagantulaAgnes VialeChristine A Iacobuzio-DonahueTing ZhouRichard M RansohoffRichard Chesworthnull nullOmar Abdel-WahabBertrand BoissonOlivier ElementoJean-Laurent CasanovaW Todd MillerFrederic Geissmann

Published in: bioRxiv : the preprint server for biology (2024)

A subset of Alzheimer Disease patients carry mutant microglia somatic clones which promote neuro-inflammation.

Keyphrases

oxidative stress
inflammatory response
ejection fraction
newly diagnosed
neuropathic pain
mild cognitive impairment
cognitive decline
patient reported outcomes
dna methylation
peritoneal dialysis
wild type