Reisolation and Configurational Reinvestigation of Cottoquinazolines E-G from an Arthropod-Derived Strain of the Fungus Neosartorya fischeri.
Shuang LinHuimin YuBeiye YangFengli LiXia ChenHuaqiang LiSitian ZhangJianping WangYou-Cai HuZheng-Xi HuYong-Hui ZhangPublished in: Journal of natural products (2020)
The reported fumiquinazoline-related alkaloids cottoquinazolines E-G (1-3) were reisolated from solid cultures of the fungus Neosartorya fischeri, which was isolated from the medicinal arthropod Cryptotympana atrata. The unresolved issues regarding the absolute configurations (for cottoquinazolines E and F) prompted a reinvestigation of the configurations for all three compounds, as enabled by extensive spectroscopic methods, comparisons of experimental electronic circular dichroism data, and X-ray crystallography. In addition, cottoquinazoline F (2) showed significant antibacterial activity against ESBL-producing Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus faecalis with MIC values of 8, 32, 32, and 16 μg/mL, respectively.
Keyphrases
- acinetobacter baumannii
- escherichia coli
- pseudomonas aeruginosa
- multidrug resistant
- klebsiella pneumoniae
- drug resistant
- biofilm formation
- cystic fibrosis
- molecular docking
- electronic health record
- high resolution
- big data
- silver nanoparticles
- dual energy
- staphylococcus aureus
- magnetic resonance
- mass spectrometry
- magnetic resonance imaging