Mutational pattern off homologous recombination repair (HRR)-related genes in upper tract urothelial carcinoma.

Kaiwei YangWei YuHuanhuan LiuFeng LouShanbo CaoHuina WangZhisong He

Published in: Cancer medicine (2023)

Our results imply that the detection of HRR gene mutations can predict recurrence in patients with UC. In addition, this study provides a path to explore the role of HRR-directed therapies, including PARPis, chemotherapy, and immunotherapy.

Keyphrases

dna repair
dna damage
radiation therapy
loop mediated isothermal amplification
free survival
chemotherapy induced