Recent advances in multifunctional dendrimer-based nanoprobes for breast cancer theranostics.
Prashant KesharwaniRahul ChadarRahul ShuklaGaurav K JainGeeta AggarwalMohammed A S AbourehabAmirhossein SahebkarPublished in: Journal of biomaterials science. Polymer edition (2022)
Breast cancer (BC) undoubtedly is one of the most common type of cancers amongst women, which causes about 5 million deaths annually. The treatments and diagnostic therapy choices currently available for Breast Cancer is very much limited . Advancements in novel nanocarrier could be a promising strategy for diagnosis and treatments of this deadly disease. Dendrimer nanoformulation could be functionalized and explored for efficient targeting of overexpressed receptors on Breast Cancer cells to achieve targeted drug delivery, for diagnostics and to overcome the resistance of the cells towards particular chemotherapeutic. Additionally, the dendrimer have shown promising potential in the improvement of therapeutic value for Breast Cancer therapy by achieving synergistic co-delivery of chemotherapeutics and genetic materials for multidirectional treatment. In this review, we have highlighted the application of dendrimer as novel multifunctional nanoplatforms for the treatment and diagnosis of Breast Cancer.
Keyphrases
- cancer therapy
- drug delivery
- breast cancer risk
- drug release
- breast cancer cells
- gene expression
- dna methylation
- cell death
- cell cycle arrest
- skeletal muscle
- oxidative stress
- climate change
- cell proliferation
- signaling pathway
- photodynamic therapy
- bone marrow
- high resolution
- metabolic syndrome
- pregnancy outcomes
- metal organic framework
- molecularly imprinted