Granulocyte macrophage colony-stimulating factor-induced macrophages of individuals with autism spectrum disorder adversely affect neuronal dendrites through the secretion of pro-inflammatory cytokines.
Ryohei TakadaMichihiro ToritsukaTakahira YamauchiRio IshidaYoshinori KayashimaYuki NishiMitsuru IshikawaKazuhiko YamamuroMinobu IkeharaTakashi KomoriYuki NoriyamaKohei KamikawaYasuhiko SaitoHideyuki OkanoManabu MakinodanPublished in: Molecular autism (2024)
Our co-culture system revealed the non-cell autonomous adverse effects of GM-CSF MΦ in individuals with ASD on neurons, mediated by interleukin-1α and TNF-α. These results may support the immune dysfunction hypothesis of ASD, providing new insights into its pathology.
Keyphrases
- autism spectrum disorder
- single cell
- attention deficit hyperactivity disorder
- high glucose
- intellectual disability
- rheumatoid arthritis
- diabetic rats
- oxidative stress
- spinal cord
- adipose tissue
- cell therapy
- peripheral blood
- endothelial cells
- spinal cord injury
- cerebral ischemia
- adverse drug
- brain injury
- subarachnoid hemorrhage
- bone marrow
- working memory
- stress induced