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Meso-Substituted Corroles from Nitrosoalkenes and Dipyrromethanes.

Susana M M LopesTeresa M V D Pinho E Melo
Published in: The Journal of organic chemistry (2020)
The synthesis of bilanes and hexapyrroles containing an oxime functionality, prepared by two and three consecutive hetero-Diels-Alder reactions (or conjugated additions) between nitrosoalkenes and dipyrromethanes, is described. Bilanes underwent oxidative macrocyclization to afford a new class of trans-A2B-corroles. Porphyrins could also be obtained by reacting bilanes with aldehydes in the presence of trifluoroacetic acid, followed by an oxidative step.
Keyphrases
  • photodynamic therapy
  • molecular docking