B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade.
Sangwoo S KimSarek A ShenSayuri MiyauchiP Dominick SandersIda Franiak-PietrygaLoren MellJ Silvio GutkindEzra E W CohenJoseph A CalifanoAndrew B SharabiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
These findings establish a key role for B cells in patient outcomes and responses to PD-1 blockade in HPV-associated squamous cell carcinomas and demonstrate the need for additional diagnostics and therapeutics targeting B cells.