Metachromatic leukodystrophy and transplantation: remyelination, no cross-correction.
Nicole I WolfMarjolein BreurBonnie PlugShanice BeerepootAimee S R WesterveldDiane F van RappardSharon I de VriesMaarten H P KoleAdeline VanderverMarjo S van der KnaapCaroline A LindemansPeter M van HasseltJaap J BoelensUlrich MatznerVolkmar GieselmannMarianna BugianiPublished in: Annals of clinical and translational neurology (2020)
In conclusion, donor macrophages are able to digest accumulated sulfatides and may play a neuroprotective role for resident oligodendrocytes, thereby enabling remyelination, albeit without evidence of cross-correction of oligo- and astroglia. These results emphasize the importance of immunomodulation in addition to the metabolic correction, which might be exploited for improved outcomes.