IFNγ mediates the resistance of tumor cells to distinct NK cell subsets.
Tomáš HofmanSiu Wang NgIrene Garcés-LázaroFlorian HeigwerMichael BoutrosAdelheid CerwenkaPublished in: Journal for immunotherapy of cancer (2024)
Our data reveal that in the context of NK cells, IFNγ induces the resistance of tumor cells by the upregulation of classical and non-classical MHC-I. Moreover, we reveal insights into NK cell subset reactivity and propose a therapeutic strategy involving combinational monalizumab/lirilumab/DX9 treatment to fully restore the antitumor response across NK cell subsets.