Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2 S Therapy.
Jie LiXiang LiYan YuanQi WangLisi XieYunlu DaiWenjun WangLin LiXiaomei LuQu-Li FanWei HuangPublished in: Small (Weinheim an der Bergstrasse, Germany) (2020)
The incidence of triple-negative breast cancer (TNBC) is difficult to predict, and TNBC has a high mortality rate among women worldwide. In this study, a theranostics approach is developed for TNBC with ratiometric photoacoustic monitored thiol-initiated hydrogen sulfide (H2 S) therapy. The ratiometric photoacoustic (PA) probe (CY) with a thiol-initiated H2 S donor (PSD) to form a nanosystem (CY-PSD nanoparticles) is integrated. In this theranostics approach, H2 S generated from PSD is sensed by CY based on ratiometric PA signals, which simultaneously pinpoints the tumor region. Additionally, H2 S is cytotoxic toward TNBC cells (MDA-MB 231), showing a tumor inhibition rate of 63%. To further verify its pharmacological mechanism, proteomics analysis is performed on tumors treated with CY-PSD nanoparticles. Cells are killed by the significant mitochondrial dysfunction via supressed energy supply and apoptosis initiation. Besides, the observed inhibition of oxidative stress also generates the cytotoxicity. Significant Kyoto Encyclopedia of Genes Genomes pathways related to TNBC are found to be inhibited. This H2 S theranostics approach updates the current anticancer therapies which brings promise for women suffering malignant breast cancer.
Keyphrases
- cell cycle arrest
- living cells
- fluorescent probe
- quantum dots
- induced apoptosis
- oxidative stress
- sensitive detection
- cell death
- endoplasmic reticulum stress
- hydrogen peroxide
- pi k akt
- polycystic ovary syndrome
- risk factors
- energy transfer
- mass spectrometry
- signaling pathway
- cardiovascular events
- type diabetes
- mesenchymal stem cells
- gene expression
- single molecule
- transcription factor
- adipose tissue
- diabetic rats
- pregnant women
- cervical cancer screening
- young adults
- artificial intelligence
- label free