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Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry.

Thomas P BrouwerNatasja L de VriesTamim AbdelaalRicki T KrogZheng LiDina RuanoArantza FariñaBoudewijn P F LelieveldtHans MorreauBert A BonsingAlexander L VahrmeijerFrits KoningNoel F C C de Miranda
Published in: Journal for immunotherapy of cancer (2022)
Our work demonstrates an immunosuppressive landscape in PDAC tissues, generally deprived of cytotoxic T cells and enriched in regulatory T cells and B cells. The antitumor potential of ILC1-like cells in PDAC may be exploited in a therapeutic setting. Importantly, immune profiles detected in blood isolated from the portal vein reflected the immune cell composition of the PDAC microenvironment, suggesting that this anatomical location could be a source of tumor-associated immune cell subsets.
Keyphrases
  • regulatory t cells
  • single cell
  • rna seq
  • endothelial cells
  • dendritic cells
  • high throughput
  • stem cells
  • gene expression
  • induced pluripotent stem cells
  • human health
  • risk assessment
  • anti inflammatory