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Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse.

Robin E KrugerTristan FrumA Sophie BrummStephanie L HickeyKathy K NiakanFarina AzizMarcelio A ShammamiJada G RobertsAmy Ralston
Published in: bioRxiv : the preprint server for biology (2024)
-dependent signaling is first active after mouse embryo implantation, when it promotes epiblast morphogenesis non-cell autonomously.
Keyphrases
  • single cell
  • epithelial mesenchymal transition
  • cell therapy
  • transforming growth factor
  • stem cells
  • pregnant women
  • mesenchymal stem cells
  • bone marrow
  • signaling pathway
  • pregnancy outcomes