Novel N(SCF 3 )(CF 3 )-amines: synthesis, scalability and stability.

We disclosed herein a straightforward strategy for the synthesis of unprecedented N -((trifluoromethyl)thio), N -(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.