Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson's disease.

Giulietta Maria RiboldiRicardo A VialleElisa NavarroEvan UdineKatia de Paiva LopesJack HumphreyAmanda AllanMadison ParksBrooklyn HendersonKelly AstudilloCharalambos ArgyrouMaojuan ZhuangTamjeed SikderJ Oriol NarcisShilpa Dilip KumarWilliam JanssenAllison SowaGiacomo P ComiAlessio Di FonzoJohn F CrarySteven J FruchtTowfique Raj

Published in: Molecular neurodegeneration (2022)

Overall, our transcriptomic analysis of primary monocytes identified gene targets and biological processes that can help in understanding the pathogenic mechanisms associated with GBA mutations in the context of PD.

Keyphrases

single cell
rna seq
genome wide
dendritic cells
peripheral blood
copy number
gene expression
dna methylation
genome wide identification
transcription factor