Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma.

Valeria LucariniOmbretta MelaiuSilvia D'AmicoFabio PastorinoPatrizia TemporaMarco ScarsellaMarco PezzulloAdele De NinnoValentina D'OriaMichele CilliLaura EmionitePaola InfanteLucia Di MarcotullioMaria Antonietta De IorisGiovanni BarillariRita AlaggioLuca BusinaroMirco PonzoniFranco LocatelliDoriana Fruci

Published in: Journal of experimental & clinical cancer research : CR (2022)

Combined treatment with low-dose of MTX and anti-TGFβ treatment with PD-1 blockade improves antitumor immunity by remodelling the tumor immune landscape and overcoming the immunosuppressive microenvironment of aggressive NB.

Keyphrases

low dose
stem cells

single cell
epithelial mesenchymal transition

signaling pathway

replacement therapy