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Antibiotic exposure for culture-negative early-onset sepsis in late-preterm and term newborns: an international study.

Varvara DimopoulouClaus KlingenbergLars NavérViveka NordbergAlberto BerardiSalhab El HelouGerhard FuschJoseph M BlissDirk LehnickNicholas GuerinaJoanna Seliga-SiweckaPierre MatonDonatienne LagaeJudit MariJan JanotaPhilipp K A AgyemanRiccardo PfisterGiuseppe LatorreGianfranco MaffeiNicola LaforgiaEnikő MózesKetil StørdalTobias StrunkMartin StockerEric Giannoninull null
Published in: Pediatric research (2024)
In a study of 757,979 infants born in high-income countries, we report a presumed culture-negative early-onset sepsis incidence of 10.6/1000 livebirths with an associated antibiotic exposure of 77 antibiotic days per 1000 livebirths. This study sheds light on the major contribution of presumed culture-negative early-onset sepsis to early-life antibiotic exposure. Given the diagnostic uncertainty surrounding culture-negative early-onset sepsis, the low mortality rate, and the disproportionate antibiotic exposure associated with this condition, our study emphasizes the importance of targeting culture-negative early-onset sepsis in antimicrobial stewardship programs.
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