Reduced dopamine transporter availability in drug-naive adult attention-deficit/hyperactivity disorder.
Shuntaro ItagakiTakashi OhnishiWataru TodaAya SatoJunya MatsumotoHiroshi ItoShiro IshiiRyo YamakuniItaru MiuraHirooki YabePublished in: PCN reports : psychiatry and clinical neurosciences (2024)
In drug-naive adult patients with ADHD, DAT availability was reduced in the nucleus accumbens, an important part of the reward system. This finding indicates the importance of the DAT in the reward system in the pathogenesis of ADHD. Inattentiveness was associated with DAT availability in the caudate nucleus, suggesting involvement of the cortico-striato-thalamo-cortical circuit.