Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease.

Fang HuMeng XueYang LiYi-Jie JiaZong-Ji ZhengYan-Lin YangMei-Ping Guan Liao Sun Yao-Ming Xue

Published in: Journal of diabetes research (2018)

Our study provides strong evidence that Egr1 is a transcriptional activator of NOX4 in oxidative stress of DKD. Egr1 contributes to DKD by enhancing EMT, in part by targeting NOX4.

Keyphrases

oxidative stress
reactive oxygen species
nuclear factor
gene expression
transcription factor
dna damage
heat shock
ischemia reperfusion injury
type diabetes
epithelial mesenchymal transition
induced apoptosis
diabetic rats
toll like receptor
inflammatory response
endoplasmic reticulum stress