Change in Viability and Function of Pancreatic Islets after Coculture with Mesenchymal Stromal Cells: A Systemic Review and Meta-Analysis.

Xiaohang LiHongxin LangBaifeng LiChengshuo ZhangNing SunJianzhen LinJialin Zhang

Published in: Journal of diabetes research (2020)

Coculture of islets with MSCs improves insulin secretory function of islets and enhances islet viability. Direct coculture of two cells significantly increased islet viability. MSC-based strategy may be beneficial for clinical islet transplantation for type 1 diabetes in the future.

Keyphrases

type diabetes
induced apoptosis
glycemic control
bone marrow
cell cycle arrest
insulin resistance
stem cells
current status
oxidative stress
cell death
endoplasmic reticulum stress
cell therapy
signaling pathway
cell proliferation