A new efficient method to detect genetic interactions for lung cancer GWAS.

Jennifer LuyapanXuemei JiSiting LiXiangjun XiaoDakai ZhuEric J DuellDavid C ChristianiMatthew B SchabathSusanne M ArnoldShanbeh ZienolddinyHans BrunnströmOlle MelanderMark D ThornquistTodd A MacKenzieChristopher I AmosJiang Gui

Published in: BMC medical genomics (2020)

From the results of our extensive simulations and analysis of a large GWAS study, we demonstrated that our method is an efficient algorithm that identified genetic interactions to include in our models to predict survival outcomes.

Keyphrases

genome wide
machine learning
deep learning
molecular dynamics
gene expression
monte carlo