Venous Collagenosis as Pathogenesis of White Matter Hyperintensity.

David LahnaDaniel L SchwartzRandy WoltjerSandra E BlackNatalie RoeseHiroko DodgeErin L BoespflugJulia KeithFuqiang GaoJoel RamirezLisa C Silbert

Published in: Annals of neurology (2022)

These findings are consistent with a model in which venous collagenosis mediates the relationship between vascular risk factors and pvWMH. This study confirms the importance of changes to the venous system in contributing to MRI white matter lesions commonly observed with advanced age. ANN NEUROL 2022;92:992-1000.

Keyphrases

white matter
risk factors
multiple sclerosis
magnetic resonance imaging
contrast enhanced
diffusion weighted imaging