Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway.
Yu-Ming WangRan JiWei-Wei ChenShun-Wei HuangYan-Jun ZhengZhi-Tao YangHong-Ping QuHao ChenEn-Qiang MaoYing ChenEr-Zhen ChenPublished in: Drug design, development and therapy (2019)
Collectively, these results indicated paclitaxel could significantly alleviate acute lung injury in CLP-induced septic mice and LPS-stimulated lung type II epithelial cell line A549 by activating MUC1 and suppressing TLR-4/NF-κB pathway.