An extract of phase II and III trials on recent developments in managing neuropathic pain syndromes: diabetic peripheral neuropathy, trigeminal neuralgia, and postherpetic neuralgia.
William C UpshawLenise G SoileauNicholas R StoreyKassady A PerkinsonPatrick M LutherNoah J SpillersChristopher L RobinsonBenjamin C MillerShahab AhmadzadehOmar ViswanathSahar ShekoohiAlan D KayePublished in: Expert opinion on emerging drugs (2024)
All the mentioned targets for treatments of NP seem to be promising alternatives for existing treatments that often possess poor side effect profiles for patients. However, gene therapy potentially offers the unique ability to inject a plasmid containing growth factors leading to nerve growth and repair. Because of this, gene therapy appears to be the most intriguing new treatment for NP.
Keyphrases
- gene therapy
- neuropathic pain
- phase ii
- spinal cord
- end stage renal disease
- spinal cord injury
- clinical trial
- newly diagnosed
- escherichia coli
- ejection fraction
- open label
- chronic kidney disease
- type diabetes
- oxidative stress
- prognostic factors
- peritoneal dialysis
- crispr cas
- anti inflammatory
- wound healing
- peripheral nerve