Comparative pathogenicity of Scedosporium species in murine model of systemic scedosporiosis.
Mariana Elizondo-ZertucheOrlando Flores-MaldonadoGloria M GonzálezMiguel A Becerril-GarcíaPublished in: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (2023)
Systemic scedosporiosis is a devastating emerging fungal infection caused by several species of the genus Scedosporium in immunocompetent and immunocompromised individuals. In this study, we compared the virulence of different Scedosporium species in a murine model of systemic scedosporiosis by survival assays, fungal burden and histopathological analysis. We found that mice mortality was species-dependent, S. apiospermum, S. aurantiacum and S. dehoogii were the most virulent species. We also observed the dissemination and invasion of Scedosporium species to the brain, spleen and kidney by colony count and histopathological analysis at different times of infection. Particularly, the brain was the tissue most susceptible to invasion during systemic scedosporiosis. This study shows the virulence and pathophysiology of different Scedosporium species and will be useful in facilitating control and prevention strategies for systemic scedosporiosis.
Keyphrases
- escherichia coli
- pseudomonas aeruginosa
- antimicrobial resistance
- metabolic syndrome
- resting state
- type diabetes
- intensive care unit
- cell migration
- multiple sclerosis
- coronary artery disease
- brain injury
- blood brain barrier
- high fat diet induced
- acute respiratory distress syndrome
- single cell
- respiratory failure
- cell wall
- candida albicans