Systemic serotonin inhibits brown adipose tissue sympathetic nerve activity via a GABA input to the dorsomedial hypothalamus, not via 5HT1A receptor activation in raphe pallidus.

Clarissa M D Mota Luiz G S BrancoShaun F MorrisonChristopher J Madden

Published in: Acta physiologica (Oxford, England) (2019)

The systemic 5-HT-induced inhibition of BAT SNA requires a GABAergic inhibition of BAT sympathoexcitatory neurones in the DMH. In addition, during warming, 5-HT released endogenously in rRPa inhibits BAT SNA.

Keyphrases

adipose tissue
drug induced
high glucose
deep brain stimulation
diabetic rats
insulin resistance
high fat diet
type diabetes
prefrontal cortex
oxidative stress
peripheral nerve