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GSH-Triggered NO releasing nanoplatform based on a covalent organic framework for "1 + 1 > 2" synergistic cancer therapy.

Xiuyan WanTeng ZhengDawei WangWei PanYanan GaoNa LiBo Tang
Published in: Chemical communications (Cambridge, England) (2022)
A porphyrin containing covalent organic framework (COF) was developed as the glutathione responsive nitric oxide (NO) donor delivery nanoplatform for "1 + 1 > 2" synergistic cancer therapy of NO mediated therapy and photodynamic therapy.
Keyphrases
  • cancer therapy
  • photodynamic therapy
  • nitric oxide
  • drug delivery
  • fluorescence imaging
  • water soluble
  • nitric oxide synthase
  • hydrogen peroxide
  • stem cells
  • fluorescent probe
  • cell therapy
  • replacement therapy