Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy.
Lauren A MarcathKelley M KidwellKiran VangipuramChristina L GerschJames M RaeMonika L BurnessJennifer J GriggsCatherine Van PoznakDaniel F HayesEllen M Lavoie SmithN Lynn HenryAndreas S BeutlerDaniel Louis HertzPublished in: British journal of clinical pharmacology (2020)
Isolating toxicity sensitivity by accounting for exposure is a novel approach, and rs7349683 represents a promising marker for PN sensitivity that may be used to individualize paclitaxel treatment.