PHOX2B reliably distinguishes neuroblastoma among small round blue cell tumours.

Yin P HungJohn P LeeAndrew M Bellizzi Jason L Hornick

Published in: Histopathology (2017)

PHOX2B is a highly sensitive and specific immunohistochemical marker for peripheral neuroblastic tumours, including neuroblastoma. PHOX2B reliably distinguishes neuroblastoma from histological mimics such as Wilms tumour, Ewing sarcoma, and CIC-rearranged round cell sarcoma. PHOX2B negativity in two of four adult neuroblastoma cases raises the possibility that some adult neuroblastomas are of a different lineage than paediatric cases.

Keyphrases

single cell
cell therapy
emergency department
intensive care unit
young adults
childhood cancer
fluorescent probe
molecularly imprinted
light emitting