Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk.

Deirdre K TobiasAlisa K ManningJennifer WesselSridharan RaghavanKenneth E WestermanAlexander G BickDaniel DicorpoEric A WhitselJason CollinsAdolfo CorreaL Adrienne CupplesJosée DupuisMark O GoodarziXiuqing GuoBarbara HowardLeslie A LangeSimin LiuLaura M RaffieldAlex P ReinerStephen S RichKent D TaylorLesley TinkerJames G WilsonPeitao WuApril P CarsonRamachandran S VasanMyriam FornageBruce M PsatyCharles KooperbergJerome I RotterJames MeigsJoAnn E Mansonnull null

Published in: Diabetes care (2023)

CHIP was associated with higher incidence of T2D. CHIP mutations located on genes implicated in CHD and mortality were also related to T2D, suggesting shared aging-related pathology.

Keyphrases

type diabetes
high throughput
circulating tumor cells
risk factors
cardiovascular disease
cardiovascular events
genome wide
insulin resistance
gene expression
coronary artery disease
risk assessment
human health
drug induced