Transcriptomics reveals shared immunosuppressive landscapes in ventilator-associated lower respiratory tract infections (VA-LRTI) patients.

Ignacio Martín-LoechesGustavo Sganzerla MartinezAlexis GardunoRachel CusackDavid Andaluz-OjedaGuillermo Lopez-CamposDavid KelvinPaula RamirezLuis Tamayo Lomas LorenzoLorenzo Socias CrespiJesús F Bermejo-Martín

Published in: Expert review of anti-infective therapy (2023)

Our findings suggest that VAP and VAT are not so different regarding gene expression levels suggesting a degree of immunosuppression. Our results indicate a state of immunoparalysis in respiratory infections in critically ill patients.

Keyphrases

respiratory tract
gene expression
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
single cell
patient reported