Pathogenic Activation of Mesenchymal Stem Cells Is Induced by the Disease Microenvironment in Systemic Sclerosis.
Zeinab TakiElena GostjevaWilliam ThillyBodoor YaseenHenry LopezMaria MirzaZainab HassujiShivanee VigneswaranBahja Ahmed AbdiAmy HartNikita ArumallaGemma ThomasChristopher P DentonYasir SulemanHuan LiuCristina VenturiniSteven O'ReillyShiwen XuRichard StrattonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Dividing MSC-like cells are present in the SSc disease microenvironment where multiple factors, likely acting in concert, promote transdifferentiation and lead to a complex and resistant disease state.