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Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma.

Adam J LuginbuhlJennifer M JohnsonLarry A HarshyneAlban J LinnenbachSanket K ShuklaAngela AlnemriGaurav KumarDavid M CognettiJoseph M CurryNikita KotlovZoya AntyshevaSandrine DegryseKyle MannionMichael K GibsonJames NettervilleBrandee BrownRita AxelrodRalph ZinnerMadalina TulucStacey K MardekianBenjamin E LeibyAyako ShimadaMy G MahoneyUbaldo Martinez-OutschoornUlrich RodeckYoung J KimAndrew P SouthAthanassios Argiris
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Preoperative nivolumab ± tadalafil is safe in HNSCC and results in more than 50% of the patients having a pathologic treatment response of at least 20% after 4 weeks of treatment. Pretreatment specimens identified HPV status-dependent signatures that predicted response to immunotherapy while posttreatment specimens showed augmentation of the immune microenvironment with the addition of tadalafil.
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