The case for a ketogenic diet in the management of kidney disease.
Shaminie J AthinarayananCaroline G P RobertsChandan VangalaGreeshma K ShettyAmy L McKenzieThomas WeimbsJeff S VolekPublished in: BMJ open diabetes research & care (2024)
Ketogenic diets have been widely used for weight loss and are increasingly used in the management of type 2 diabetes. Despite evidence that ketones have multiple positive effects on kidney function, common misconceptions about ketogenic diets, such as high protein content and acid load, have prevented their widespread use in individuals with impaired kidney function. Clinical trial evidence focusing on major adverse kidney events is sparse. The aim of this review is to explore the effects of a ketogenic diet, with an emphasis on the pleiotropic actions of ketones, on kidney health. Given the minimal concerns in relation to the potential renoprotective effects of a ketogenic diet, future studies should evaluate the safety and efficacy of ketogenic interventions in kidney disease.
Keyphrases
- weight loss
- bariatric surgery
- physical activity
- clinical trial
- roux en y gastric bypass
- gastric bypass
- healthcare
- public health
- mental health
- glycemic control
- human health
- adipose tissue
- emergency department
- binding protein
- skeletal muscle
- small molecule
- risk assessment
- insulin resistance
- social media
- protein protein
- double blind
- study protocol