C. difficile infection (CDI) is a costly and increasing burden on the healthcare systems of many developed countries due to the high rates of nosocomial infections. Despite the availability of several antibiotics with high response rates, effective treatment is hampered by recurrent infections. One potential mechanism for recurrence is the existence of C. difficile biofilms in the gut which persist through the course of antibiotics. In this review, we describe current developments in understanding the molecular mechanisms by which C. difficile biofilms form and are stabilized through extracellular biomolecular interactions.
Keyphrases
- clostridium difficile
- biofilm formation
- candida albicans
- healthcare
- pseudomonas aeruginosa
- staphylococcus aureus
- escherichia coli
- high resolution
- risk factors
- cystic fibrosis
- methicillin resistant staphylococcus aureus
- klebsiella pneumoniae
- mass spectrometry
- human health
- social media
- combination therapy
- health information
- free survival
- multidrug resistant