Evaluation of the frequency of ADIPOQ c.45 T>G and ADIPOQ c.276 G>T polymorphisms in adiponectin coding gene in girls with anorexia nervosa.

Karolina N Ziora-Jakutowicz Janusz Grzegorz Zimowski Katarzyna Ziora Małgorzata Bednarska-Makaruk Elżbieta Świętochowska Piotr Gorczyca Jakub Gamrot Edyta Machura Małgorzata Stojewska Gołąb-Jenerał KatarzynaMałgorzata BlaskaElżbieta Mizgała-Izworska Michal Kukla Filip Rybakowski

Published in: Endokrynologia Polska (2021)

The genotype in loci ADIPOQ c.45 and ADIPOQ c.276 of the ADIPO gene seems to have no effect on the predisposition to AN. Girls suffering from AN with the TT genotype in loci ADIPOQ c.45 and ADIPOQ c. 276 may demonstrate higher insulin sensitivity because they have significantly higher levels of ADIPO than girls suffering from AN with other genotypes. This may be suggestive of their better adaptation to the state of malnutrition, and it has a potential effect on treatment results.

Keyphrases

genome wide
anorexia nervosa
copy number
metabolic syndrome
insulin resistance
type diabetes
adipose tissue
genome wide identification
genome wide association
climate change
replacement therapy