A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer.

Erik Bovinder YlitaloElin ThysellMattias LandforsMaria BrattsandEmma JernbergSead CrnalicAnders WidmarkMagnus HultdinAnders BerghSofie DegermanPernilla Wikström

Published in: Clinical epigenetics (2021)

A promoter methylation signature classifies PC bone metastases into two groups and predicts tumor AR activity and patient prognosis after ADT. The explanation for the methylation diversities observed during PC progression and their biological and clinical relevance need further exploration.

Keyphrases

dna methylation
prostate cancer
genome wide
case report
gene expression
squamous cell carcinoma
small cell lung cancer
radical prostatectomy
transcription factor
copy number
body composition