Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages.

Siyuan TianXia ZhouMiao ZhangLina CuiBo LiYansheng LiuRui SuKeshuai SunYinan HuFangfang YangGuoyun XuanShuoyi MaXiaohong ZhengXinmin ZhouChangcun GuoYulong ShangJingbo WangYing Han

Published in: Stem cell research & therapy (2022)

These findings suggest that MSC-EXOs protect against liver fibrosis via delivering miR-148a that regulates intrahepatic macrophage functions through KLF6/STAT3 signaling and provide a potential therapeutic target for liver fibrosis.

Keyphrases

liver fibrosis
cell proliferation
mesenchymal stem cells
long non coding rna
long noncoding rna
transcription factor
stem cells
bone marrow
adipose tissue
umbilical cord
risk assessment