Comparative Analysis of MSC-Derived Exosomes Depending on Cell Culture Media for Regenerative Bioactivity.

Jun Yong KimWon-Kyu RhimHyo Jeong SeoJoo Youn LeeChun Gwon ParkDong Keun Han

Published in: Tissue engineering and regenerative medicine (2021)

CDM has the advantages to maintain cell proliferation even during the period of exosome isolations and eliminate unknown side effects caused by serum-derived exosomes. Additionally, exosomes derived from UCMSC cultured with CDM show better wound healing and angiogenic effects due to a lot of regeneration-related cytokines and less pro-inflammatory cytokines compared to with NM.

Keyphrases

stem cells
mesenchymal stem cells
wound healing
cell proliferation
cell therapy
bone marrow
photodynamic therapy
endothelial cells
signaling pathway