The outward shift of clarithromycin binding to the ribosome in mutant Helicobacter pylori strains.

Najmeh Salehi Bahareh AttaranFatemeh Zare-MirakabadBahareh GhadiriMaryam EsmaeiliMohadeseh ShakaramMohammad TashakoripourMahmoud Eshagh HosseiniMarjan Mohammadi

Published in: Helicobacter (2020)

Our data suggest that, in mutant H pylori strains, once the nucleotides at positions 2142 and 2587 are detached from the drug, CLA interacts with and is peeled back by the L4 accessory protein, removing the drug-imposed spatial restriction of the NPET.

Keyphrases

helicobacter pylori
helicobacter pylori infection
escherichia coli
wild type
binding protein
electronic health record
adverse drug
emergency department
big data
amino acid