Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia.
Rim TradWalid WardaVincent AlcazerMathieu Neto da RochaAna BerceanuClémentine NicodRafik HaderbacheXavier RousselYohan DesbrossesEtienne DaguindauFlorain RenosiChristophe RoumierLucie BouquetSabeha BiichleMelanie GuiotEvan SeffarDenis CaillotStephane DepilEric RobinetYahya SalmaEric DeconinckMarina DeschampsChristophe FerrandPublished in: Journal for immunotherapy of cancer (2022)
In conclusion, our preclinical results suggest that IL-1RAP CAR T-based adoptive therapy could be a promising strategy in AML treatment and it warrants the clinical investigation of this CAR T-cell therapy.