Gentulizumab, a novel anti-CD47 antibody with potent antitumor activity and demonstrates a favorable safety profile.
Tao WangSi-Qin WangYin-Xiao DuDan-Dan SunChang LiuShuang LiuYing-Ying SunHai-Long WangChun-Sheng ZhangHai-Long LiuLei JinXiao-Ping ChenPublished in: Journal of translational medicine (2024)
GenSci059 selectively binds to CD47, effectively blocks the CD47/SIRPα axis signaling pathway and enhances the phagocytosis effects of macrophages toward tumor cells. This monoclonal antibody demonstrates potent antitumor activity and exhibits a favorable safety profile, positioning it as a promising and effective therapeutic option for cancer.